Multilayer OMIC Data in Medullary Thyroid Carcinoma Identifies the STAT3 Pathway as a Potential Therapeutic Target in RETM918T Tumors.

doi:10.1158/1078-0432.CCR-16-0947

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Article

Multilayer OMIC Data in Medullary Thyroid Carcinoma Identifies the STAT3 Pathway as a Potential Therapeutic Target in RETM918T Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2017

Mancikova Veronika, Montero-Conde Cristina, Perales-Paton Javier, Fernandez Agustin, Santacana María, Jodkowska Karolina, Inglada-Pérez Lucia, Castelblanco Esmeralda, Borrego Salud, Encinas Mario, Matias-Guiu Xavier, Fraga Mario, Robledo Mercedes

Abstract excerpt

Purpose: Medullary thyroid carcinoma (MTC) is a rare disease with few genetic drivers, and the etiology specific to each known susceptibility mutation remains unknown. Exploiting multilayer genomic data, we focused our interest on the role of aberrant DNA methylation in MTC development.Experimental Design: We performed genome-wide DNA methylation profiling assessing more than 27,000 CpGs in the largest MTC series...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27620278
DOI: 10.1158/1078-0432.CCR-16-0947

Genes

STAT3
DKK4
MMP20
PLCB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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