An inherited genetic variant of the CEP72 gene is associated with the development of vincristine-induced peripheral neuropathy in female patients with aggressive B-cell lymphoma.

doi:10.1007/s00277-024-05973-9

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Article

An inherited genetic variant of the CEP72 gene is associated with the development of vincristine-induced peripheral neuropathy in female patients with aggressive B-cell lymphoma.

Annals of hematology - 1 Nov 2024

Christofyllakis Konstantinos, Kaddu-Mulindwa Dominic, Lesan Vadim, Rixecker Torben, Kos Igor Age, Held Gerhard, Regitz Evi, Pfreundschuh Michael, Bittenbring Joerg Thomas, Thurner Lorenz, Poeschel Viola, Ziepert Marita, Altmann Bettina, Bewarder Moritz

Abstract excerpt

Vincristine-induced peripheral neuropathy (VIPN) is an adverse effect of regimens used for the treatment of aggressive B-cell non-Hodgkin lymphoma (B-NHL). A single-nucleotide polymorphism (SNP) in the promotor region of the CEP72 gene has been identified as risk factor for the development of VIPN in children. To validate these results in adults we aimed to determine the association of the high-risk CEP72...

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PMID: 39227453
DOI: 10.1007/s00277-024-05973-9
PMCID: PMC11534822

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