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Article

Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity.

PLoS pathogens - 1 Jun 2011

Haim Hillel, Strack Bettina, Kassa Aemro, Madani Navid, Wang Liping, Courter Joel R, Princiotto Amy, McGee Kathleen, Pacheco Beatriz, Seaman Michael S, Smith Amos B, Sodroski Joseph

Abstract excerpt

Human immunodeficiency virus (HIV-1) enters cells following sequential activation of the high-potential-energy viral envelope glycoprotein trimer by target cell CD4 and coreceptor. HIV-1 variants differ in their requirements for CD4; viruses that can infect coreceptor-expressing cells that lack CD4 have been generated in the laboratory. These CD4-independent HIV-1 variants are sensitive to neutralization by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21731494
DOI: 10.1371/journal.ppat.1002101
PMCID: PMC3121797

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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