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Article

Effects of Genetic Polymorphisms of Cytochrome P450 Enzymes and MDR1 Transporter on Pantoprazole Metabolism and Helicobacter pylori Eradication.

Basic & clinical pharmacology & toxicology - 1 Feb 2017

Karaca R Ozgur, Kalkisim Said, Altinbas Akif, Kilincalp Serta, Yuksel Ilhami, Goktas Mustafa T, Yasar Umit, Bozkurt Atilla, Babaoglu Melih O

Abstract excerpt

Pantoprazole is a proton pump inhibitor that is commonly used in the treatment of peptic ulcer disease (PUD) and metabolized by cytochrome P450 (CYP) enzymes CYP2C19 and CYP3A4. Pantoprazole is a substrate for multi-drug resistance protein 1 (MDR1). Single nucleotide polymorphisms (SNPs) in CYP2C19, CYP3A4 and MDR1 affect enzyme activity or gene expression of proteins and may alter plasma pantoprazole...

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PMID: 27611887
DOI: 10.1111/bcpt.12667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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