Article
Effects of CYP2C19 and MDR1 genotype on the eradication rate of Helicobacter pylori infection by triple therapy with pantoprazole, amoxycillin and clarithromycin.
Journal of gastroenterology and hepatology - 1 Feb 2009
Oh Jung-Hwan, Dong Mi-Sook, Choi Myung-Gyu, Yoo Hae-Won, Lee Sang-Bum, Park Young In, Chung In-Sik
Abstract excerpt
BACKGROUND: CYP2C19 polymorphism plays an important role in the metabolism of proton pump inhibitors. The multidrug resistance (MDR)1 genotype is associated with the successful eradication of Helicobacter pylori. The aim of the present study was to investigate the effects of CYP2C19 and MDR1 genotypes on the eradication rate of H. pylori using a pantoprazole-based triple therapy. METHODS: A total of 210 patients...
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