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Article

CYP2C19 polymorphism influences Helicobacter pylori eradication.

World journal of gastroenterology - 21 Nov 2014

Kuo Chao-Hung, Lu Chien-Yu, Shih Hsiang-Yao, Liu Chung-Jung, Wu Meng-Chieh, Hu Huang-Ming, Hsu Wen-Hung, Yu Fang-Jung, Wu Deng-Chyang, Kuo Fu-Chen

Abstract excerpt

The known factors that have contributed to the decline of Helicobacter pylori (H. pylori) eradication rate include antibiotic resistance, poor compliance, high gastric acidity, high bacterial load, and cytochrome P450 2C19 (CYP2C19) polymorphism. Proton pump inhibitor (PPI) is important in the eradication regimen. The principal enzyme implicated in the metabolism of PPIs is CYP2C19. The effects of PPI depend on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25473155
DOI: 10.3748/wjg.v20.i43.16029
PMCID: PMC4239489

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