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Article

Pten and EphB4 regulate the establishment of perisomatic inhibition in mouse visual cortex.

Nature communications - 9 Sept 2016

Baohan Amy, Ikrar Taruna, Tring Elaine, Xu Xiangmin, Trachtenberg Joshua T

Abstract excerpt

Perisomatic inhibition of pyramidal neurons is established by fast-spiking, parvalbumin-expressing interneurons (PV cells). Failure to assemble adequate perisomatic inhibition is thought to underlie the aetiology of neurological dysfunction in seizures, autism spectrum disorders and schizophrenia. Here we show that in mouse visual cortex, strong perisomatic inhibition does not develop if PV cells lack a single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27611660
DOI: 10.1038/ncomms12829
PMCID: PMC5023968

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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