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Article

Frequent activation of EGFR in advanced chordomas

25 Jul 2011

Abstract excerpt

BACKGROUND: Chordomas are rare neoplasms, arising from notochordal remnants in the midline skeletal axis, for which the current treatment is limited to surgery and radiotherapy. Recent reports suggest that receptor tyrosine kinases (RTK) might be essential for the survival or proliferation of chordoma cells, providing a rationale for RTK targeted therapy. Nevertheless, the reported data are conflicting, most...

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PMID: 22613809
DOI: 10.1186/2045-3329-1-4

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