Article
Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas.
PloS one - 8 Sept 2010
Corbo Vincenzo, Ritelli Rossana, Barbi Stefano, Funel Niccola, Campani Daniela, Bardelli Alberto, Scarpa Aldo
Abstract excerpt
BACKGROUND: Protein kinases are key regulators of cellular processes (such as proliferation, apoptosis and invasion) that are often deregulated in human cancers. Accordingly, kinase genes have been the first to be systematically analyzed in human tumors leading to the discovery that many oncogenes correspond to mutated kinases. In most cases the genetic alterations translate in constitutively active kinase...
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