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Article

Promoting transcription of chromosome ends

28 Oct 2010

Abstract excerpt

We recently identified CpG island promoters driving transcription of human telomeric repeat-containing RNA (TERRA). This discovery has shaped a new concept in telomere biology, where TERRA promoters and downstream telomeric sequences constitute autonomous genic units.

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Share to RNA modifications and cancer
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Share to Telomeres, Telomerase, and Senescence

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Identifiers

PMID: 21326888
DOI: 10.4161/trns.1.3.13191

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Promoting transcription of chromosome endsPMID 21326888Read ↗

CpG-island promoters drive transcription of human telomeresSemantic proximity Read ↗

Expression and differential regulation of human TERRA at several chromosome endsSemantic proximity Read ↗

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The Emerging Roles of TERRA in Telomere Maintenance and Genome StabilitySemantic proximity Read ↗

TERRA ONTseq: a long-read-based sequencing pipeline to study the human telomeric transcriptomeSemantic proximity Read ↗

TERRA ONTseq: a long read-based sequencing pipeline to study the human telomeric transcriptomeSemantic proximity Read ↗

TERRA Promotes Telomere Shortening through Exonuclease 1–Mediated Resection of Chromosome EndsSemantic proximity Read ↗

Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integritySemantic proximity Read ↗

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short TelomeresSemantic proximity Read ↗

R-Loops at Chromosome Ends: From Formation, Regulation, and Cellular ConsequenceSemantic proximity Read ↗

The THO complex counteracts TERRA R-loop-mediated telomere fragility in telomerase+ cells and telomeric recombination in ALT+ cellsSemantic proximity Read ↗

TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cellsSemantic proximity Read ↗

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