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Article

Normal spastin gene dosage is specifically required for axon regeneration.

Cell reports - 29 Nov 2012

Stone Michelle C, Rao Kavitha, Gheres Kyle W, Kim Seahee, Tao Juan, La Rochelle Caroline, Folker Christin T, Sherwood Nina T, Rolls Melissa M

Abstract excerpt

Axon regeneration allows neurons to repair circuits after trauma; however, most of the molecular players in this process remain to be identified. Given that microtubule rearrangements have been observed in injured neurons, we tested whether microtubule-severing proteins might play a role in axon regeneration. We found that axon regeneration is extremely sensitive to levels of the microtubule-severing protein...

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Share to Adenosine Triphosphatases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23122959
DOI: 10.1016/j.celrep.2012.09.032
PMCID: PMC3513560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Normal spastin gene dosage is specifically required for axon regeneration.PMID 23122959Read ↗

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Spastin Is Required to Prevent SPAST-Related Demyelination.Semantic proximity Read ↗

Models of axon regeneration in Drosophila.Semantic proximity Read ↗

A mutation of spastin is responsible for swellings and impairment of transport in a region of axon characterized by changes in microtubule composition.Semantic proximity Read ↗

The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans.Semantic proximity Read ↗

The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches.Semantic proximity Read ↗

SkpA restrains synaptic terminal growth during development and promotes axonal degeneration following injury.Semantic proximity Read ↗

Pleiotropic effects of spastin on neurite growth depending on expression levels.Semantic proximity Read ↗

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