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Article

SFL production by carcinoma cells induces the aggressive properties of nonproducing cells in vivo via a community effect.

Invasion & metastasis - 1 Jan 2000

Bellusci S, Moens G, Delouvée A, Thiery J P, Jouanneau J

Abstract excerpt

A metastatic rat bladder carcinoma cell line, M-NBT-II, produces and secretes a dissociating factor called SFL, whereas the tumorigenic parental cell line from which it originated (E-NBT-II) does not. In this work, we report that SFL production is correlated with an invasive phenotype in three-dimensional collagen gels or organotypic cocultures. This invasiveness may be related to the production of gelatinolytic...

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PMID: 7657525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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