Suppression of respiratory growth defect of mutant deficient in mitochondrial phospholipase A1 by overexpression of genes involved in coenzyme Q synthesis in Saccharomyces cerevisiae.

Abstract excerpt

DDL1 encodes a mitochondrial phospholipase A1 involved in acyl chain remodeling of mitochondrial phospholipids and degradation of cardiolipin in Saccharomyces cerevisiae. The deletion of DDL1 leads to respiratory growth defects. To elucidate the physiological role of DDL1, we screened for genes that, when overexpressed, suppress the respiratory growth defect of the DDL1 deletion mutant. Introduction of COQ8,...

Topics

• Electron Transport
• Gene Deletion
• Gene Expression Regulation, Fungal
• Genes, Fungal
• Genetic Vectors
• Mitochondria
• Mutation
• Phospholipases A1
• Saccharomyces cerevisiae
• Saccharomyces cerevisiae Proteins