Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LSY-2 is essential for maintaining the germ-soma distinction in C. elegans.

Protein & cell - 1 Aug 2015

Lin Long, Li Yuping, Yan Libo, Zhang Gangming, Zhao Yu, Zhang Hong

Abstract excerpt

The mechanisms that specify and maintain the characteristics of germ cells during animal development are poorly understood. In this study, we demonstrated that loss of function of the zinc-finger gene lsy-2 results in various somatic cells adopting germ cells characteristics, including expression of germline-specific P granules, enhanced RNAi activity and transgene silencing. The soma to germ transformation in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Animals, Genetically Modified
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Caenorhabditis elegans Proteins

Share to Fluorescent Antibody Technique, Indirect

Share to Genes, Essential

Share to Germ Cells

Share to RNA Interference

Source

Open in PubMed Open full text

Identifiers

PMID: 26050091
DOI: 10.1007/s13238-015-0173-1
PMCID: PMC4506282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LSY-2 is essential for maintaining the germ-soma distinction in C. elegans.PMID 26050091Read ↗

Specification of the germ lineSemantic proximity Read ↗

MEG-1 and MEG-2 are embryo-specific P-granule components required for germline development in Caenorhabditis elegans.Semantic proximity Read ↗

Identification of regulators of germ stem cell enwrapment by its niche in C. elegansSemantic proximity Read ↗

Systematic identification of germ granule proteins reveals specialized roles in RNAi and small RNA inheritance.Semantic proximity Read ↗

Systematic Identification of Germ Granule Proteins Reveals Specialized Roles in RNAi and Small RNA InheritanceSemantic proximity Read ↗

MEP-1 and a Homolog of the NURD Complex Component Mi-2 Act Together to Maintain Germline-Soma Distinctions in C. elegansSemantic proximity Read ↗

PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans.Semantic proximity Read ↗

The conserved phosphatase GSP-2/PP1 promotes germline immortality via small RNA-mediated genome silencing during meiosisSemantic proximity Read ↗

The zinc-finger transcription factor LSL-1 is a major regulator of the germline transcriptional program in <i>C. elegans</i>Semantic proximity Read ↗

Germ granule association drives small RNA specificity for a nuclear Argonaute proteinSemantic proximity Read ↗

A Forward Genetic Screen for Suppressors of Somatic P Granules in Caenorhabditis elegans.Semantic proximity Read ↗

The Germline-Specific Factor OEF-1 Facilitates Coordinated Progression Through Germ Cell Development in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.