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Article

Esrrb directly binds to Gata6 promoter and regulates its expression with Dax1 and Ncoa3.

Biochemical and biophysical research communications - 30 Sept 2016

Uranishi Kousuke, Akagi Tadayuki, Koide Hiroshi, Yokota Takashi

Abstract excerpt

Estrogen-related receptor beta (Esrrb) is expressed in embryonic stem (ES) cells and is involved in self-renewal ability and pluripotency. Previously, we found that Dax1 is associated with Esrrb and represses its transcriptional activity. Further, the disruption of the Dax1-Esrrb interaction increases the expression of the extra-embryonic endoderm marker Gata6 in ES cells. Here, we investigated the influences of...

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PMID: 27601327
DOI: 10.1016/j.bbrc.2016.09.011

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