Article
Efficient capture of cardiogenesis-associated genes expressed in ES cells.
Biochemical and biophysical research communications - 30 Mar 2007
Terami Hiromi, Hidaka Kyoko, Shirai Manabu, Narumiya Hiromichi, Kuroyanagi Takuo, Arai Yuji, Aburatani Hiroyuki, Morisaki Takayuki
Abstract excerpt
Cardiogenesis can be induced in vitro in ES cells, though it is difficult to distinguish cardiac-specific genes, since embryoid bodies simultaneously differentiate into multiple lineages. In the present study, transient serum removal during culture greatly enhanced cardiogenesis, and reduced generation of endothelial and hematopoietic cells. Using DNA microarray analysis of 24 differentiated sample cultures...
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