Article
Impact of APOL1 polymorphism and IL-1β priming in the entry and persistence of HIV-1 in human podocytes.
Retrovirology - 6 Sept 2016
Mikulak Joanna, Oriolo Ferdinando, Portale Federica, Tentorio Paolo, Lan Xiqian, Saleem Moin A, Skorecki Karl, Singhal Pravin C, Mavilio Domenico
Abstract excerpt
BACKGROUND: Patients of African ancestry with untreated HIV-1 infection and carrying the G1 or G2 kidney disease risk variants (Vs) at the APOL1 gene have a tenfold higher risk of developing HIV-associated nephropathy (HIVAN) compared to those with the non-risk wild type (WT) G0 variant. However, the mechanistic contribution of the APOL1 allelic state to kidney injury in HIV-1 infection remains to be elucidated....
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