Article
Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormality in multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Aug 2015
Niino Masaaki, Sato Shinya, Fukazawa Toshiyuki, Yoshimura Satoshi, Hisahara Shin, Matsushita Takuya, Isobe Noriko, Yoshida Kazuto, Houzen Hideki, Miyazaki Yusei, Shimohama Shun, Kikuchi Seiji, Kira Jun-ichi
Abstract excerpt
BACKGROUND: It is unclear whether the prevalence of oligoclonal IgG bands (OCBs) in multiple sclerosis (MS) is different between northern and southern regions of Asia. OBJECTIVE: This study aimed to compare the prevalence of OCBs and positive cerebrospinal fluid (CSF) findings between northern and southern regions of Japan and to investigate the association of these CSF findings with HLA-DRB1 alleles. METHODS:...
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