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Article

Identification of Multiple Gene Mutations Accounts for a new Genetic Architecture of Primary Ovarian Insufficiency.

The Journal of clinical endocrinology and metabolism - 1 Dec 2016

Bouilly Justine, Beau Isabelle, Barraud Sara, Bernard Valérie, Azibi Kemal, Fagart Jérôme, Fèvre Anne, Todeschini Anne Laure, Veitia Reiner A, Beldjord Chérif, Delemer Brigitte, Dodé Catherine, Young Jacques, Binart Nadine

Abstract excerpt

CONTEXT: Idiopathic primary ovarian insufficiency (POI) is a major cause of amenorrhea and infertility. POI affects 1% of women before age 40 years, and several genetic causes have been reported. To date, POI has been considered a monogenic disorder. OBJECTIVE: The aim of this study was to identify novel gene variations and to investigate if individuals with POI harbor mutation in multiple loci. PATIENTS AND...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27603904
DOI: 10.1210/jc.2016-2152

Genes

BMP15
FIGLA
FOXL2
GALT
GDF9
LHX8
NOBOX
REC8
SOHLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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