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Article

Murine MTHFD1-synthetase deficiency, a model for the human MTHFD1 R653Q polymorphism, decreases growth of colorectal tumors.

Molecular carcinogenesis - 1 Mar 2017

Lévesque Nancy, Christensen Karen E, Van Der Kraak Lauren, Best Ana F, Deng Liyuan, Caldwell Don, MacFarlane Amanda J, Beauchemin Nicole, Rozen Rima

Abstract excerpt

The common R653Q variant (∼20% homozygosity in Caucasians) in the synthetase domain of the folate-metabolizing enzyme MTHFD1 reduces purine synthesis. Although this variant does not appear to affect risk for colorectal cancer, we questioned whether it would affect growth of colorectal tumors. We induced tumor formation in a mouse model for MTHFD1-synthetase deficiency (Mthfd1S+/- ) using combined administration...

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Identifiers

PMID: 27597531
DOI: 10.1002/mc.22568

Genes

MTHFD1
TNF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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