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Article

Filamin-regulated F-actin assembly is essential for morphogenesis and controls phototaxis in Dictyostelium.

The Journal of biological chemistry - 19 Jan 2007

Khaire Nandkumar, Müller Rolf, Blau-Wasser Rosemarie, Eichinger Ludwig, Schleicher Michael, Rief Matthias, Holak Tad A, Noegel Angelika A

Abstract excerpt

Dictyostelium strains lacking the F-actin cross-linking protein filamin (ddFLN) have a severe phototaxis defect at the multicellular slug stage. Filamins are rod-shaped homodimers that cross-link the actin cytoskeleton into highly viscous, orthogonal networks. Each monomer chain of filamin is com...

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Identifiers

PMID: 17121815
DOI: 10.1074/jbc.M610262200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17121815-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Filamin-regulated F-actin assembly is essential for morphogenesis and controls phototaxis in Dictyostelium.PMID 17121815Read ↗

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