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Article

Filamin-regulated F-actin assembly is essential for morphogenesis and controls phototaxis in Dictyostelium.

The Journal of biological chemistry - 19 Jan 2007

Khaire Nandkumar, Müller Rolf, Blau-Wasser Rosemarie, Eichinger Ludwig, Schleicher Michael, Rief Matthias, Holak Tad A, Noegel Angelika A

Abstract excerpt

Dictyostelium strains lacking the F-actin cross-linking protein filamin (ddFLN) have a severe phototaxis defect at the multicellular slug stage. Filamins are rod-shaped homodimers that cross-link the actin cytoskeleton into highly viscous, orthogonal networks. Each monomer chain of filamin is comprised of an F-actin-binding domain and a rod domain. In rescue experiments only intact filamin re-established correct...

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PMID: 17121815
DOI: 10.1074/jbc.M610262200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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