Article
Filamin actin-binding and titin-binding fulfill distinct functions in Z-disc cohesion.
PLoS genetics - 1 Jul 2017
González-Morales Nicanor, Holenka Tristan K, Schöck Frieder
Abstract excerpt
Many proteins contribute to the contractile properties of muscles, most notably myosin thick filaments, which are anchored at the M-line, and actin thin filaments, which are anchored at the Z-discs that border each sarcomere. In humans, mutations in the actin-binding protein Filamin-C result in myopathies, but the underlying molecular function is not well understood. Here we show using Drosophila indirect flight...
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