Article
Association of polymorphisms in genes of factors involved in regulation of splicing of cystic fibrosis transmembrane conductance regulator mRNA with acute respiratory distress syndrome in children with pneumonia.
Critical care (London, England) - 5 Sept 2016
Perez-Marques Francesca, Simpson Pippa, Yan Ke, Quasney Michael W, Halligan Nadine, Merchant Daniel, Dahmer Mary K
Abstract excerpt
BACKGROUND: Previous work has demonstrated a strong association between lung injury in African American children with pneumonia and a polymorphic (TG)mTn region in cystic fibrosis transmembrane conductance (CFTR) involved in the generation of a nonfunctional CFTR protein lacking exon 9. A number of splicing factors that regulate the inclusion/exclusion of exon 9 have been identified. The objective of this study...
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