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Article

Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits.

Neuron - 21 Sept 2016

McAvoy Kathleen M, Scobie Kimberly N, Berger Stefan, Russo Craig, Guo Nannan, Decharatanachart Pakanat, Vega-Ramirez Hugo, Miake-Lye Sam, Whalen Michael, Nelson Mark, Bergami Matteo, Bartsch Dusan, Hen Rene, Berninger Benedikt, Sahay Amar

Abstract excerpt

The neural circuit mechanisms underlying the integration and functions of adult-born dentate granule cell (DGCs) are poorly understood. Adult-born DGCs are thought to compete with mature DGCs for inputs to integrate. Transient genetic overexpression of a negative regulator of dendritic spines, Kruppel-like factor 9 (Klf9), in mature DGCs enhanced integration of adult-born DGCs and increased NSC activation....

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Identifiers

PMID: 27593178
DOI: 10.1016/j.neuron.2016.08.009
PMCID: PMC5033725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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