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Effect of Cytotoxic Chemotherapy on Markers of Molecular Age in Patients With Breast Cancer

28 Mar 2014

Abstract excerpt

BACKGROUND: Senescent cells, which express p16 (INK4a) , accumulate with aging and contribute to age-related pathology. To understand whether cytotoxic agents promote molecular aging, we measured expression of p16 (INK4a) and other senescence markers in breast cancer patients treated with adjuvant chemotherapy. METHODS: Blood and clinical information were prospectively obtained from 33 women with stage I to III...

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PMID: 24681605
DOI: 10.1093/jnci/dju057

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