Immunosenescence profile and expression of the aging biomarker (p16INK4a) in testicular cancer survivors treated with chemotherapy.

Abstract excerpt

<title>Abstract</title> <p><underline>Background:</underline> Cytotoxic chemotherapy can cure advanced germ cell tumors. Nevertheless, cancer treatment may induce cellular senescence and accelerate molecular aging. The aging process implies an increase of cells expressing <italic>p16</italic>^{<italic>INK4a</italic>} and changes in lymphocyte subpopulations. Our aim was to study the potential induction of...

Topics

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• Cell Cycle
• Cell Line, Tumor
• Cellular Senescence
• Cytomegalovirus and herpesvirus research
• Disease Models, Animal
• Gene Expression Regulation, Neoplastic
• Mice, Inbred BALB C
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

556d00aa-95b8-565f-bcd2-1ae80b6524cc

DOI

10.21203/rs.2.13836/v4