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GATA3 as a master regulator and therapeutic target in ovarian high‐grade serous carcinoma stem cells

14 Jul 2018

Abstract excerpt

Ovarian high-grade serous carcinoma (HGSC) is the most lethal gynecological malignancy. Prevailing evidences suggest that drug resistance and recurrence of ovarian HGSC are caused by the presence of cancer stem cells. Therefore, targeting cancer stems is appealing, however, all attempts to date, have failed. To circumvent this limit, we analyzed differential transcriptomes at early differentiation of ovarian HGSC...

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Chromatin Remodeling and Cancer
Epigenetics and DNA Methylation
Metastasis and carcinoma case studies

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PMID: 30006927
DOI: 10.1002/ijc.31750

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