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Article

A SIRT1-centered circuitry regulates breast cancer stemness and metastasis

23 Jul 2018

Abstract excerpt

Cancer stem cell (CSC)-dictated intratumor heterogeneity accounts for the majority of drug-resistance and distant metastases of breast cancers. Here, we identify a SIRT1-PRRX1-KLF4-ALDH1 circuitry, which couples CSCs, chemo-resistance, metastasis and aging. Pro-longevity protein SIRT1 deacetylates and stabilizes the epithelial-to-mesenchymal-transition (EMT) inducer PRRX1, which inhibits the transcription of core...

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PMID: 30038266
DOI: 10.1038/s41388-018-0370-5

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