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Claudin-low-like mouse mammary tumors show distinct transcriptomic patterns uncoupled from genomic drivers

31 Jul 2019

Abstract excerpt

BACKGROUND: Claudin-low breast cancer is a molecular subtype associated with poor prognosis and without targeted treatment options. The claudin-low subtype is defined by certain biological characteristics, some of which may be clinically actionable, such as high immunogenicity. In mice, the medroxyprogesterone acetate (MPA) and 7,12-dimethylbenzanthracene (DMBA)-induced mammary tumor model yields a heterogeneous...

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PMID: 31366361
DOI: 10.1186/s13058-019-1170-8

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