Article
Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 14 Nov 2023
Paolino Jonathan, Dimitrov Boris, Apsel Winger Beth, Sandoval-Perez Angelica, Rangarajan Amith Vikram, Ocasio-Martinez Nicole, Tsai Harrison K, Li Yuting, Robichaud Amanda L, Khalid Delan, Hatton Charlie, Gillani Riaz, Polonen Petri, Dilig Anthony, Gotti Giacomo, Kavanagh Julia, Adhav Asmani A, Gow Sean, Tsai Jonathan, Li Yen Der, Ebert Benjamin L, Van Allen Eliezer M, Bledsoe Jacob, Kim Annette S, Tasian Sarah K, Cooper Stacy L, Cooper Todd M, Hijiya Nobuko, Sulis Maria Luisa, Shukla Neerav N, Magee Jeffrey A, Mullighan Charles G, Burke Michael J, Luskin Marlise R, Mar Brenton G, Jacobson Matthew P, Harris Marian H, Stegmaier Kimberly, Place Andrew E, Pikman Yana
Abstract excerpt
PURPOSE: Patients with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) or lymphoblastic lymphoma (T-LBL) have limited therapeutic options. Clinical use of genomic profiling provides an opportunity to identify targetable alterations to inform therapy. EXPERIMENTAL DESIGN: We describe a cohort of 14 pediatric patients with relapsed or refractory T-ALL enrolled on the Leukemia Precision-based...
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