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Article

A phosphatase threshold sets the level of Cdk1 activity in early mitosis in budding yeast.

Molecular biology of the cell - 1 Oct 2011

Harvey Stacy L, Enciso Germán, Dephoure Noah, Gygi Steven P, Gunawardena Jeremy, Kellogg Douglas R

Abstract excerpt

Entry into mitosis is initiated by synthesis of cyclins, which bind and activate cyclin-dependent kinase 1 (Cdk1). Cyclin synthesis is gradual, yet activation of Cdk1 occurs in a stepwise manner: a low level of Cdk1 activity is initially generated that triggers early mitotic events, which is followed by full activation of Cdk1. Little is known about how stepwise activation of Cdk1 is achieved. A key regulator of...

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Identifiers

PMID: 21849476
DOI: 10.1091/mbc.E11-04-0340
PMCID: PMC3183015

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