Article
Neurocognitive function varies by IDH1 genetic mutation status in patients with malignant glioma prior to surgical resection.
Neuro-oncology - 1 Dec 2016
Wefel Jeffrey S, Noll Kyle R, Rao Ganesh, Cahill Daniel P
Abstract excerpt
BACKGROUND: Patients with malignant gliomas present with variation in neurocognitive function (NCF) not attributable to lesion size or location alone. A potential contributor is the rate at which tumors grow, or "lesion momentum." Isocitrate dehydrogenase 1 wild type (IDH1-WT) are more proliferative and aggressive than IDH1-mutant (IDH1-M) tumors. We hypothesized that patients with IDH1-WT would exhibit worse NCF...
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