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Article

Voxel-wise radiogenomic mapping of tumor location with key molecular alterations in patients with glioma.

Neuro-oncology - 9 Oct 2018

Tejada Neyra Miguel Angel, Neuberger Ulf, Reinhardt Annekathrin, Brugnara Gianluca, Bonekamp David, Sill Martin, Wick Antje, Jones David T W, Radbruch Alexander, Unterberg Andreas, Debus Jürgen, Heiland Sabine, Schlemmer Heinz-Peter, Herold-Mende Christel, Pfister Stefan, von Deimling Andreas, Wick Wolfgang, Capper David, Bendszus Martin, Kickingereder Philipp

Abstract excerpt

Background: This study aims to evaluate the impact of tumor location on key molecular alterations on a single voxel level in patients with newly diagnosed glioma. Methods: A consecutive series of n = 237 patients with newly diagnosed glioblastoma and n = 131 patients with lower-grade glioma was analyzed. Volumetric tumor segmentation was performed on preoperative MRI with a semi-automated approach and images were...

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Identifiers

PMID: 30107597
DOI: 10.1093/neuonc/noy134
PMCID: PMC6176804

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