Article
IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection.
Neuro-oncology - 1 Jan 2014
Beiko Jason, Suki Dima, Hess Kenneth R, Fox Benjamin D, Cheung Vincent, Cabral Matthew, Shonka Nicole, Gilbert Mark R, Sawaya Raymond, Prabhu Sujit S, Weinberg Jeffrey, Lang Frederick F, Aldape Kenneth D, Sulman Erik P, Rao Ganesh, McCutcheon Ian E, Cahill Daniel P
Abstract excerpt
BACKGROUND: IDH1 gene mutations identify gliomas with a distinct molecular evolutionary origin. We sought to determine the impact of surgical resection on survival after controlling for IDH1 status in malignant astrocytomas-World Health Organization grade III anaplastic astrocytomas and grade IV glioblastoma. METHODS: Clinical parameters including volumetric assessment of preoperative and postoperative MRI were...
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