Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Retrospective Association Analysis of Binary Traits: Overcoming Some Limitations of the Additive Polygenic Model.

Human heredity - 1 Jan 2015

Jiang Duo, Mbatchou Joelle, McPeek Mary Sara

Abstract excerpt

Case-control genetic association analysis is an extremely common tool in human complex trait mapping. From a statistical point of view, the analysis of binary traits poses somewhat different challenges from the analysis of quantitative traits. Desirable features of a binary trait mapping approach would include (1) phenotype modeled as binary, with appropriate dependence between the mean and variance; (2)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computer Simulation
Share to Models, Genetic
Share to Multifactorial Inheritance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Quantitative Trait, Heritable

Source

Open in PubMed Open full text

Identifiers

PMID: 27576759
DOI: 10.1159/000446957
PMCID: PMC5505235

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Retrospective Association Analysis of Binary Traits: Overcoming Some Limitations of the Additive Polygenic Model.PMID 27576759Read ↗

CERAMIC: Case-Control Association Testing in Samples with Related Individuals, Based on Retrospective Mixed Model Analysis with Adjustment for Covariates.Semantic proximity Read ↗

L-GATOR: Genetic Association Testing for a Longitudinally Measured Quantitative Trait in Samples with Related Individuals.Semantic proximity Read ↗

Estimating missing heritability for disease from genome-wide association studies.Semantic proximity Read ↗

Retrospective analysis of main and interaction effects in genetic association studies of human complex traits.Semantic proximity Read ↗

MASTOR: mixed-model association mapping of quantitative traits in samples with related individuals.Semantic proximity Read ↗

Case-control association mapping without casesSemantic proximity Read ↗

Retrospective Binary-Trait Association Test Elucidates Genetic Architecture of Crohn Disease.Semantic proximity Read ↗

Single marker association analysis for unrelated samples.Semantic proximity Read ↗

Single Marker Association Analysis for Unrelated Samples.Semantic proximity Read ↗

Covariate adjusted inference of parent-of-origin effects using case-control mother-child paired multilocus genotype data.Semantic proximity Read ↗

Secondary phenotype analysis in ascertained family designs: application to the Leiden longevity study.Semantic proximity Read ↗

Methods for testing association between uncertain genotypes and quantitative traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.