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Article

Retrospective analysis of main and interaction effects in genetic association studies of human complex traits.

BMC genetics - 16 Oct 2007

Tan Qihua, Christiansen Lene, Brasch-Andersen Charlotte, Zhao Jing Hua, Li Shuxia, Kruse Torben A, Christensen Kaare

Abstract excerpt

BACKGROUND: The etiology of multifactorial human diseases involves complex interactions between numerous environmental factors and alleles of many genes. Efficient statistical tools are demanded in identifying the genetic and environmental variants that affect the risk of disease development. This paper introduces a retrospective polytomous logistic regression model to measure both the main and interaction...

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Identifiers

PMID: 17937824
DOI: 10.1186/1471-2156-8-70
PMCID: PMC2099440

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