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Article

Accuracy of Gene Scores when Pruning Markers by Linkage Disequilibrium.

Human heredity - 1 Jan 2015

Dudbridge Frank, Newcombe Paul J

Abstract excerpt

OBJECTIVE: Gene scores are often used to model the combined effects of genetic variants. When variants are in linkage disequilibrium, it is common to prune all variants except the most strongly associated. This avoids duplicating information but discards information when variants have independent effects. However, joint modelling of correlated variants increases the sampling error in the gene score. In recent...

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PMID: 27576758
DOI: 10.1159/000446581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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