Measuring linkage disequilibrium and improvement of pruning and clumping in structured populations

Abstract excerpt

Standard measures of linkage disequilibrium (LD) are affected by admixture and population structure, such that loci that are not in LD within each ancestral population appear linked when considered jointly. The influence of population structure on LD can cause problems for downstream analysis methods, in particular those that rely on LD pruning or clumping. To address this issue, we propose a measure of LD that ac...

Topics

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• Gene Frequency
• FST gene
• Genetics, Population
• Genome, Human
• Linkage Disequilibrium
• Models, Genetic
• Polymorphism, Single Nucleotide
• Principal Component Analysis

Identifiers and source

Literature Corpus work

f247418a-49d2-5a87-977d-3320eb83200d

DOI

10.1101/2024.05.02.592187