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Article

Tumor volume determines the feasibility of cell-free DNA sequencing for mutation detection in non-small cell lung cancer.

Cancer science - 1 Nov 2016

Ohira Tatsuo, Sakai Kazuko, Matsubayashi Jun, Kajiwara Naohiro, Kakihana Masatoshi, Hagiwara Masaru, Hibi Masaaki, Yoshida Koichi, Maeda Junichi, Ohtani Keishi, Nagao Toshitaka, Nishio Kazuto, Ikeda Norihiko

Abstract excerpt

Next-generation sequencing (NGS) and digital PCR technologies allow analysis of the mutational profile of circulating cell-free DNA (cfDNA) in individuals with advanced lung cancer. We have now evaluated the feasibility of cfDNA sequencing for mutation detection in patients with non-small cell lung cancer at earlier stages. A total of 150 matched tumor and serum samples were collected from non-small cell lung...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 27575703
DOI: 10.1111/cas.13068
PMCID: PMC5132294

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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