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Article

The relevance of tumor mutation profiling in interpretation of NGS data from cell-free DNA in non-small cell lung cancer patients.

Experimental and molecular pathology - 1 Feb 2020

Ottestad Anine Larsen, Wahl Sissel G F, Grønberg Bjørn Henning, Skorpen Frank, Dai Hong Yan

Abstract excerpt

Studies have indicated that detection of circulating tumor DNA (ctDNA) prior to treatment is a negative prognostic marker in non-small cell lung cancer (NSCLC). ctDNA is currently identified by detection of tumor mutations. Commercial next-generation sequencing (NGS) assays for mutation analysis of ctDNA for routine practice usually include small gene panels and are not suitable for general mutation analysis. In...

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Identifiers

PMID: 31759951
DOI: 10.1016/j.yexmp.2019.104347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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