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Article

Prospective clinical evaluation of cell-free DNA next generation sequencing in patients with suspected metastatic lung cancer.

Scientific reports - 8 Apr 2026

Steendam Christi M J, Meijers Ruud W J, Atmodimedjo Peggy, van Dijk Lisette, van der Leest Cor, van Loenhout Keetie C J, van 't Westeinde Susan C, Dumoulin Daphne W, Hanselaar Wessel E J J, Paats Marthe S, de Jonge Evert, van Schaik Ron H N, von der Thüsen Jan H, Aerts Joachim G J V, Dingemans Anne-Marie C, Dubbink Hendrikus Jan

Abstract excerpt

Molecular analysis of tumor material is standard in metastatic non-squamous non-small cell lung cancer (NSCLC), but it is not always feasible, limiting targeted treatment options. We investigated the clinical value of cell-free DNA (cfDNA) next-generation sequencing (NGS) in patients with clinically and radiologically suspected metastatic NSCLC. Within the comprehensive cancer network Southwest (The Netherlands),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41951723
DOI: 10.1038/s41598-026-47197-z
PMCID: PMC13219393

Genes

AGA
BRAF
KRAS
EGFR
NRAS
PIK3CA
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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