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Article

Association between Type A blaZ Gene Polymorphism and Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Nov 2016

Lee Sun Hee, Park Wan Beom, Lee Shinwon, Park Sohee, Kim Shin Woo, Lee Jong-Myung, Chang Hyun Ha, Kwon Ki Tae, Choe Pyoeng Gyun, Kim Nam Joong, Kim Hong Bin, Oh Myoung-Don

Abstract excerpt

Some proportion of type A blaZ gene-positive methicillin-susceptible Staphylococcus aureus strains exhibit the cefazolin inoculum effect (CIE). The type A blaZ gene was divided into two groups by single nucleotide polymorphisms (SNPs) at Ser226Pro and Cys229Tyr. The median cefazolin MICs at a high inoculum concentration were 5.69 μg/ml for the Ser-Cys group and 40.32 μg/ml for the Pro-Tyr group (P = 0.01). The...

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Identifiers

PMID: 27572417
DOI: 10.1128/AAC.01517-16
PMCID: PMC5075110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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