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Article

Inoculum effect of high concentrations of methicillin-susceptible Staphylococcus aureus on the efficacy of cefazolin and other beta-lactams.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Mar 2018

Saeki Masachika, Shinagawa Masaaki, Yakuwa Yuki, Nirasawa Shinya, Sato Yuki, Yanagihara Nozomi, Takahashi Satoshi

Abstract excerpt

The existence of a cefazolin inoculum effect (InE) of methicillin-susceptible Staphylococcus aureus (MSSA), which is speculated to be a reason for cefazolin treatment failure in MSSA infections, is controversial. In Japan, although cefazolin is one of the therapeutic choices for patients with MSSA infection, there are few reports of this effect. Additionally, the association between InE and blaZ type in...

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Identifiers

PMID: 29198902
DOI: 10.1016/j.jiac.2017.10.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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