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Investigation of the cefazolin inoculum effect in blood culture-isolated methicillin-susceptible Staphylococcus aureus strains: A Japanese multicenter study.

Diagnostic microbiology and infectious disease - 1 Jul 2026

Fukushima Shinnosuke, Tsuji Shuma, Gotoh Kazuyoshi, Iio Koji, Ogawa Sakura, Koyanagi Norihito, Ito Yuji, Koganemaru Hiroshi, Yoshida Atsushi, Hagiya Hideharu

Abstract excerpt

BACKGROUND: Cefazolin inoculum effect (CInE) is a microbiological phenomenon where the MIC of cefazolin against methicillin-susceptible Staphylococcus aureus (MSSA) strains increases with higher bacterial volumes. METHOD: We retrospectively investigated the prevalence and characteristics of the CInE among MSSA strains isolated from blood cultures at three Japanese hospitals. The collected isolates were screened...

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PMID: 41785539
DOI: 10.1016/j.diagmicrobio.2026.117345

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