Validation of a modified rapid test to detect the cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus from bloodstream infections in hospitals from North and Latin America

Abstract excerpt

BACKGROUND: The cefazolin inoculum effect (CzIE), defined here as a cefazolin MIC at high inoculum (107 colony-forming units/mL) ≥16 mg/L in MSSA, has been associated with less favourable clinical outcomes. However, detection of this phenotype is challenging in the clinical microbiology laboratory. We previously described modification of a rapid nitrocefin test using ampicillin disks rather than ampicillin powder...

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