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Article

Modulation of autoimmune arthritis severity in mice by apolipoprotein E (ApoE) and cholesterol.

Clinical and experimental immunology - 1 Dec 2016

Alvarez P, Genre F, Iglesias M, Augustin J J, Tamayo E, Escolà-Gil J C, Lavín B, Blanco-Vaca F, Merino R, Merino J

Abstract excerpt

Apolipoprotein E (ApoE) deficiency promoted an exacerbation of autoimmune arthritis in mice by inducing proinflammatory immune responses. In this study we analysed the contribution of hypercholesterolaemia and/or the absence of ApoE anti-inflammatory properties, unrelated to its function in the control of cholesterol metabolism, towards the acceleration of arthritis in these mutant animals. The induction and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27571306
DOI: 10.1111/cei.12857
PMCID: PMC5108071

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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