Article
Telomere length and associations with somatic mutations and clinical outcomes in acute myeloid leukemia.
Leukemia research - 1 Oct 2016
Watts Justin M, Dumitriu Bogdan, Hilden Patrick, Kishtagari Ashwin, Rapaport Franck, Chen Christina, Ahn Jihae, Devlin Sean M, Stein Eytan M, Rampal Raajit, Levine Ross L, Young Neal, Tallman Martin S
Abstract excerpt
We examined the genetic implications and clinical impact of telomere length (TL) in 67 patients with acute myeloid leukemia (AML). There was a trend toward improved survival at 6 months in patients with longer TL. We found that patients with activating mutations, such as FLT3-ITD, had shorter TL, while those with mutations in epigenetic modifying enzymes, particularly IDH1 and IDH2, had longer TL. These are...
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