Article
Interindividual Variation in DNA Methylation at a Putative POMC Metastable Epiallele Is Associated with Obesity.
Cell metabolism - 13 Sept 2016
Kühnen Peter, Handke Daniela, Waterland Robert A, Hennig Branwen J, Silver Matt, Fulford Anthony J, Dominguez-Salas Paula, Moore Sophie E, Prentice Andrew M, Spranger Joachim, Hinney Anke, Hebebrand Johannes, Heppner Frank L, Walzer Lena, Grötzinger Carsten, Gromoll Jörg, Wiegand Susanna, Grüters Annette, Krude Heiko
Abstract excerpt
The estimated heritability of human BMI is close to 75%, but identified genetic variants explain only a small fraction of interindividual body-weight variation. Inherited epigenetic variants identified in mouse models named "metastable epialleles" could in principle explain this "missing heritability." We provide evidence that methylation in a variably methylated region (VMR) in the pro-opiomelanocortin gene...
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