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Article

Epigenetic regulation of POMC; implications for nutritional programming, obesity and metabolic disease

1 Jul 2019

Abstract excerpt

Proopiomelanocortin (POMC) is a key mediator of satiety. Epigenetic marks such as DNA methylation may modulate POMC expression and provide a biological link between early life exposures and later phenotype. Animal studies suggest epigenetic marks at POMC are influenced by maternal energy excess and restriction, prenatal stress and Triclosan exposure. Postnatal factors including energy excess, folate, vitamin A,...

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Identifiers

PMID: 31344387
DOI: 10.1016/j.yfrne.2019.100773

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