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Article

Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment

19 Jul 2023

Abstract excerpt

Increasing evidence points toward epigenetic variants as a risk factor for developing obesity. We analyzed DNA methylation of the POMC (pro-opiomelanocortin) gene, which is pivotal for satiety regulation. We identified sex-specific and nongenetically determined POMC hypermethylation associated with a 1.4-fold (confidence interval, 1.03 to 2.04) increased individual risk of developing obesity. To investigate the...

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PMID: 37467315
DOI: 10.1126/scitranslmed.adg1659

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